cGAS inhibition alleviates Alu RNA-induced immune responses and cytotoxicity in retinal pigmented epithelium
Abstract Background The degeneration of retinal pigmented epithelium (RPE) cells results in severe diseases, such as age-related macular degeneration (AMD) that causes blindness in millions of individuals.Results We report that targeting GMP-AMP (cGAMP) synthase (cGAS) alleviates Anti-Aging Alu RNA-induced immune responses and cytotoxicity in RPE.W